Dear, I am sorry for your pathetic condition. Clinical depression or depressive disorder is a neurochemical disorder. Clinical depression is usually treated with a combination of psychiatric medicines, psychotherapy, life style changes, meditation and exercise. I hope your wife is undergoing psychiatric treatment, otherwise, please approach a psychiatrist. I will not say that it is difficult to cure, for sure, it takes time. Once you make the necessary amendments in your life with the help of the above said therapies and life style changes, learn how to manage the depressive episodes without medicines and learn to relax, the medicines can be weaned off over a period of one year. The best option for you is to undergo counseling and depression related therapy. Take care.